Watch movements are an almost endless series of compromises, so asking if two barrels are better than one in isolation of all other factors is a bit of a meaningless exercise. There are other makers out there who make 3-day and 8-day movements, and Lange even made one that would run 30 or 31 days (can't recall exactly) on one wind. I also recall that the Lange was so difficult to wind they gave you a special powered tool to along with the watch so you could wind the crown.
These movement designs increase the complexity as you add in these features, and in general terms an increase in complexity typically means a decrease in reliability. They also tend to increase in size due to the additional real estate required for either one larger mainspring barrel, or two smaller barrels. Sometimes this can compromise the size of other parts in the watch, such as the balance.
One maker of 8 day watches had big troubles with overbanking when the watch was fully wound - their solution was to tell their customers to not wind the watch fully.
🤦
Unfortunately it's not so simple to say that two barrels are always better/worse than one. The devil is in the details...
Cheers, Al