To add on to your thoughts, what could trigger a change is if they decided to do another SS 321 model, like a 145.012. They could stop production of the EW and then pivot to that one next.
I feel Calibre 321 is here to stay. Omega invested a lot to resurrect it, and remember this was also their solution to upgrade the speedmaster whilst keeping a heritage baseline, a very smart move I believe. Clearly this calibre is going to be mounted in other models (like the new Canopus gold) which I have no concern with as it would just make the Ed White harder to get (considering I'm lucky to already have one!).
I understand the CEO's video above as "no more LE". This doesn't mean models will be available forever, just that they will stop releasing special editions with a hard stop on numbers (e.g. 2000 models then it's over). I feel this doesn't change anything to be honest, at least on the availability of models that are on high demand. It just makes the brand a bit more serious, as selling too many variations of an original can be perceived as gimmicky.
Now whether the Ed White itself is going to be discontinued or not... well all things have to come to an end, but I don't foresee this model to disappear in the next-coming years. And remember it is not an anniversary model like the Snoopy (which will clearly be discontinued in 2 years or when Omega says there's been enough of them). Again, I feel they have branched the speedmaster line on purpose, each and every time they upgraded the speedmaster (861, 1861, 3861) it came with some eyebrow-raising which shows how it's difficult to evolve a legend (which is a necessity in this world) whilst keeping true to its original. Resurrecting the 321 was the solution: the 321 is here to stay as a historically-correct model whilst leaving room for the 3861 to further evolve technically without looking back.
Anyhow, I've had my Ed White since Oct 2020 and I have absolutely no regret. Ultimate speedmaster. And all my speedmaster-fans friends agree - when they originally thought it was going to not be distinctive enough visually versus say an FOIS, they all changed their mind when they saw it for real... it is radically different (finish of the case, thickness, etc).