If you want some tritium - go for the early 2531.80 (all 2220.80's have Supeluminova), other than that those two are pretty similar watches which differ in;
- hands length (longer at 2220.80),
- different shades of blue, different dials,
- a case back (more detailed but taller at 2220.80),
- due to a slightly taller bezel - 2220.80 in overall is slightly taller than 2531.80
- 1120 cal. vs 2500 cal. very late 2220.80's even have had 2500D hence a different date font.
If you will service them at Omega - a standard service fee is the same for mechanical non-chronograph calibres.
Everything else is subjective and only you can tell which watch is superior. I chose 2220.80 due to the longer hands and the red Seamaster which makes the dial more vivid.
Btw, I am poor in JB franchise, but wasn't a quartz 2541.80 featured in Tomorrow Never Dies?
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