You can put a new plexiglass on it no problem. You will struggle to get a sapphire crystal to work properly so don't even bother to try. The Speedmasters fitted as std with sapphire have slightly different cases to allow them to fit. Personally I wouldn't attempt that myself, I would use a watchmaker and let him source the correct crystal.
Not sure where in the world you are but if anywhere near the UK then I would send it to Simon Freese or STS for fixing
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