I work in web design and deal with very large clients now, but when we started we took any client, because it meant making money and paying our salaries.
Eventually, you learn to say no to some clients, especially those that won't be worth the pain.
My dad is a plastic surgeon and does this all the time. After so many years, you can tell which are going to be the ones that are never happy and will try to sue you. They come for the consultation with a photo of some persons nose.. And no matter how good of a surgeon you are, you can not give an exact copy of another person's nose. So, if they are adamant about having "this person's nose" he drops them.
/Alex
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