Stories from the Front Lines (✨COVID-19 Healthcare Workers only: posting rules imposed)

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Meta-Analysis published in JAMA a couple years back indicated that peripheral thermometers (temporal membrane, oral, etc.) had poor reliability for detecting low-grade fevers. However, I am not sure how happy your clients would be if you required a rectal temp from them before being seen. Source: doi: 10.7326/M15-1150.

Having said that, another very recent study notes that only 88.7% of COVID+ patients had a fever. Not sure what your tolerance for risk is but just noting that fever is not a foolproof way of screening. Source: doi: 10.1016/j.tmaid.2020.101623

Thanks. 90% is pretty high; as an alternative to rectal, maybe oral with a sleeve?

Unfortunately there are no good screening measures. People are contagious for up to several days before they exhibit any symptoms at all. In addition there are some that don’t have any symptoms and can have active Covid infection.

If you’re going to see patients like I am doing you can wear a mask for all patients. While surgical masks afford some protection they are not as effective As an N 95 mask which has been correctly fitted. You can decrease your risk somewhat by not seeing sick patients who are coughing with a fever but it will not lower your risk to zero. You have to be able to except some risk when any patient or person is within 6 feet for any significant period of time. That is our only tool now, to reduce the number of people you see, sick or not. Stay safe.

I appreciate your insights. I was thinking about double -masking: N95 for me, common surgical mask for them. Hand-cleansing before entering the room. Window open. The hope for the best...
 
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Thanks. 90% is pretty high; as an alternative to rectal, maybe oral with a sleeve?



I appreciate your insights. I was thinking about double -masking: N95 for me, common surgical mask for them. Hand-cleansing before entering the room. Window open. The hope for the best...
I would not double mask yourself as it may impair seal. Worse, it may reduce your ability to breath effectively.
Putting a surgical mask on your pt makes good sense and is what we do when the pt is highly contagious with TB or disseminated Herpes ( These are aerosolized. Covid is also aersolized but we are working with it like it s only droplet. That is mainly cause we are short on N95. )The pt wears a surgical mask and the doc or nurse wears an N95.
 
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The pt wears a surgical mask and the doc or nurse wears an N95

Yes, thanks. This is what I was referring to with "double masking."
 
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Hi, academic hematologic oncologist and bioethicist in Boston and on our hospital ethics committee. I was on our inpatient lymphoma/leukemia service for the last two weeks, we had several cases during my time on. Was scary to see the incubation period live -- a lot of the PPE recommendations were evolving over those two weeks so we had exposures before universal masks/gloves/gowns/eye protection were implemented. We're converting some of the gen med services into COVID services and have specific COVID-Onc services for our patients with cancer with COVID but at the moment have enough PPE (now recycling N95s through a hospital sterilization program) and critical care resources. A number of U.S. hospitals, even those outside of the currently overwhelmed areas, are looking to adopt versions of Pitt's critical care resource allocation guidelines (see here), which is frightening but necessary, should the local resources become strictly scarce.

Thankfully, I am asymptomatic (and baseline low risk).
 
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Yesterday I dropped off a patient in a NYC hospital and scene was unfathomable. I need to collect myself but I'll try to share more later. These next few days in New York are going to be very very Rocky.

I heard Elmhurst is a war zone.

Today was MUCH worse. Emergently intubated 8 people. I don't care what the one case study paper says about inability to determine ACE/ARB relationships to worsening presentations of C19; I'm seeing it. And not only that, I am seeing ACEi pts presenting relatively calm, no real respiratory distress even when evidently hypoxic with sats in the 60s. My small sample size shows VBGs with low pCO2, despite no apparent hyperventilation, which to my non-doc mind is weird. Conversely, pts on ARBs are also hypoxic, but retracting and extremely distressed (and expected). ALL of them have white sheets for chest XRs.

The RRTs are usually pretty non-aggressive where I work, I'm not. I "suggested" increasing PEEP on one pt beyond the typical 5-7, bumped them up to 12, sats finally started to bounce, really came up well after being at 15, to the point that the sedation needed to be increased due to higher level of consciousness presumably because of better overall oygenation.

Going to enjoy the next few days off with some scotch.
 
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I heard Elmhurst is a war zone.

Today was MUCH worse. Emergently intubated 8 people. I don't care what the one case study paper says about inability to determine ACE/ARB relationships to worsening presentations of C19; I'm seeing it. And not only that, I am seeing ACEi pts presenting relatively calm, no real respiratory distress even when evidently hypoxic with sats in the 60s. My small sample size shows VBGs with low pCO2, despite no apparent hyperventilation, which to my non-doc mind is weird. Conversely, pts on ARBs are also hypoxic, but retracting and extremely distressed (and expected). ALL of them have white sheets for chest XRs.

The RRTs are usually pretty non-aggressive where I work, I'm not. I "suggested" increasing PEEP on one pt beyond the typical 5-7, bumped them up to 12, sats finally started to bounce, really came up well after being at 15, to the point that the sedation needed to be increased due to higher level of consciousness presumably because of better overall oygenation.

Going to enjoy the next few days off with some scotch.
I’m surprised we have not seen data put together yet on the ARB/ACEi. You would think you could age match COVID hospital patients with HTN. Then see if the outcomes shows correlate with any of the meds they were on. I would think even that could be done with the patients we have had to date.
 
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I heard Elmhurst is a war zone.

Today was MUCH worse. Emergently intubated 8 people. I don't care what the one case study paper says about inability to determine ACE/ARB relationships to worsening presentations of C19; I'm seeing it. And not only that, I am seeing ACEi pts presenting relatively calm, no real respiratory distress even when evidently hypoxic with sats in the 60s. My small sample size shows VBGs with low pCO2, despite no apparent hyperventilation, which to my non-doc mind is weird. Conversely, pts on ARBs are also hypoxic, but retracting and extremely distressed (and expected). ALL of them have white sheets for chest XRs.

The RRTs are usually pretty non-aggressive where I work, I'm not. I "suggested" increasing PEEP on one pt beyond the typical 5-7, bumped them up to 12, sats finally started to bounce, really came up well after being at 15, to the point that the sedation needed to be increased due to higher level of consciousness presumably because of better overall oygenation.

Going to enjoy the next few days off with some scotch.
Also the low CO2 could be from the hypoxia and/or large areas of infarcted lung tissue
 
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I appreciate all of the info in this thread (and all of your dedication and heroism in this crisis), but if the substantive contributors to this thread could just try to keep your lay audience in mind, that would be very helpful. Thanks in advance.

Hopefully some translations can help:

I don't care what the one case study paper says about inability to determine ACE/ARB relationships to worsening presentations of C19; I'm seeing it. And not only that, I am seeing ACEi pts presenting relatively calm, no real respiratory distress even when evidently hypoxic with sats in the 60s. My small sample size shows VBGs with low pCO2, despite no apparent hyperventilation, which to my non-doc mind is weird.

There has been talk that ACE (angiotensin converting enzyme) and ARB (aldosterone receptor blocker) inhibitors have detrimental effects to COVID+ patients. These two drugs are used to treat high blood pressure (or as the writer above notes HTN - hypertension). However, ACE inhibitors can also have effects the the blood vessels of the lungs and as such are often contraindicated in patients with other pulmonary issues such as COPD, asthma, etc. Some have suggested these drugs may also effect viral entry into the cell but thats a bit above my pay-grade at the moment. Discussion about the topic can be found here https://jamanetwork.com/journals/jama/fullarticle/2763803

@Wetworks is saying that he is seeing patients taking these medications who show no outward signs of respiratory distress (difficulty breathing), even when the "sats" (oxygen saturation) is in the 60s (normal is 90+). He goes on to explain that seeing patients with low pCO2, partial pressure of carbon dioxide on VBGs (venous blood gases) who are not hyperventilating (over breathing). Many gasses, most importantly oxygen and carbon dioxide exist in a variety of forms in our blood. We use VBGs to measure these values and assess how good or bad a job the lungs are doing on getting oxygen into your blood and CO2 out. Our various tissues require oxygen to function and in the process create CO2 as a byproduct. All these gases are very delicately balance as they (particularly CO2 in the form of bicarbonate) can have drastic effects on the pH of the blood. So what he is saying is he is seeing patients with very low levels of CO2 in the blood, creating what is called a respiratory alkylosis (making the blood too basic). This is often seen in patients are are breathing too much, and are essentially blowing off too much CO2. However, these patient dont seem to actually be hyperventilating - which is sort of mismatched.

Hope that helps!
 
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Hopefully some translations can help:



There has been talk that ACE (angiotensin converting enzyme) and ARB (aldosterone receptor blocker) inhibitors have detrimental effects to COVID+ patients. These two drugs are used to treat high blood pressure (or as the writer above notes HTN - hypertension). However, ACE inhibitors can also have effects the the blood vessels of the lungs and as such are often contraindicated in patients with other pulmonary issues such as COPD, asthma, etc. Some have suggested these drugs may also effect viral entry into the cell but thats a bit above my pay-grade at the moment. Discussion about the topic can be found here https://jamanetwork.com/journals/jama/fullarticle/2763803

@Wetworks is saying that he is seeing patients taking these medications who show no outward signs of respiratory distress (difficulty breathing), even when the "sats" (oxygen saturation) is in the 60s (normal is 90+). He goes on to explain that seeing patients with low pCO2, partial pressure of carbon dioxide on VBGs (venous blood gases) who are not hyperventilating (over breathing). Many gasses, most importantly oxygen and carbon dioxide exist in a variety of forms in our blood. We use VBGs to measure these values and assess how good or bad a job the lungs are doing on getting oxygen into your blood and CO2 out. Our various tissues require oxygen to function and in the process create CO2 as a byproduct. All these gases are very delicately balance as they (particularly CO2 in the form of bicarbonate) can have drastic effects on the pH of the blood. So what he is saying is he is seeing patients with very low levels of CO2 in the blood, creating what is called a respiratory alkylosis (making the blood too basic). This is often seen in patients are are breathing too much, and are essentially blowing off too much CO2. However, these patient dont seem to actually be hyperventilating - which is sort of mismatched.

Hope that helps!


Lol, if I could 'love' this post I would!!! Sorry @FreelanceWriter, I did not take into account that there would be lay people particularly interested in this thread, so I just spoke workspeak which @zrleopold did a terrific job of translating. Obviously he(?) is very well-versed in this.
 
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Sorry to break in as a non-professional; please tell me how they're sterilizing them, UV, Ozone, autoclave, chemical, etc. I was searching this a week ago and found nothing. I can autoclave but would hate to ruin masks that otherwise would respond to chemical with less damage.

Thanks

I'll let them answer as well, but my guess would be with the UV lights they are using for rooms. There's mechanical cleaning of the rooms as well, but I don't think the masks would hold up well to chemical disinfectants. I'm using a neck gaiter as a fomite barrier with a surgical mask in between.
 
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Took me a while to get this down... an update.

On Thursday (3/26/2020), I’m called to a familiar scene, a nursing home that we’re called to all the time. Today we are here for an elderly woman who is "uwell.” These days that means COVID-19. This nursing home has been ravaged by COVID-19 cases. There are many residents there but it's a ghost town. They have been forced into self-isolation (rightfully and for their own good). Nobody in the halls. Nobody in common areas. The place is silent.

I come in full PPE gear and the receptionist takes my temperature. Even as I'm responding to an emergency - they can't take chances. I could still be carrying asymptomatic but at least this is a small way to screen. Honestly, any EMT who has been taking calls in NYC for the past two weeks and only started wearing PPE on all calls starting this week should be considered high suspicion for COVID-19.

I walk inside and she's sitting in the bathroom, confused. She doesn't hear me but the staff says that her hearing is fine. Her mental status is off, they say, she’s usually more with it. She's breathing normally enough but isn't quite responding to me when I talk to her. I take her temperature. 102F. Dry cough. I put on a pulse-oximetry tool, she’s 88% oxygen saturation. So she's not getting enough oxygen. I start oxygen (NC 6LPM) and her numbers go up. I put in a call to a supervisor and all parties agree she needs to be transported. We take her alone. I make sure she brings her cell phone and a charger. I call the son to explain what I'm seeing and reassure him that I am caring for mom but she needs to go to the hospital.

I call ahead to the hospital, "I've got a patient high suspicion index for COVID" and I share that the O2 is low enough to raise concern. With exertion she could easily drop into the 70's. We're second in line for triage, the EMT crew in front of us with a patient who waited 2 hours for the EMTs to arrive after calling 9-1-1. Now that crew has been waiting two hours in the hospital for staff to triage their patient and even find an open bed. So there is an unbelievable bottleneck that is slowing down a 9-1-1 system that is now getting twice the call volume of any regular day.

Back to my patient. I end up getting an oxygen tank from a nurse because my portable one runs out. While we are waiting, one ER patient crashes. He goes from 80% o2 saturation down to 50's. There is a crew “bagging him” to breathe for him. They close the doors, usually that means to control for droplets that any artificial ventilation causes. They tube the patient.

I'm still with my 90+ year old patient. She's not sure why she isn't being seen yet and she can barely hear me through my N95 mask. My partner says they just started CPR "over there." A heavyset guy in his 50's, COVID+. My partner says he saw him walking around 5 minutes before. He wasn't on oxygen or hooked up to any monitor. He just crashed. The last time I saw CPR being done in a hospital they were working the patient for nearly an hour before they called it. The small crew that is able to respond takes nine or so minutes before calling it. They need to move onto the next patient who needs to be tubed. A woman in her 60's is being brought into the orthopedics room usually reserved for broken bones. Every room is a “respiratory room” now. She is breathing rapidly and just can't get enough oxygen. Not gasping for breath, but just not getting enough oxygen. I see her being spoken to by the doctors about how they are going to put her to sleep to help her breathe. The doctors are all wearing heavy PPE equipment and I can barely make out their faces. It occurs to me: This woman has no family around her. She may have just heard her last words from a doctor in a near-space suit. (I feel her loneliness for a moment...)

Back to the first EMT crew's patient. They finally find a monitor to register the patient. Heavyset guy in his mid-50's probably. I hear him talking with his EMT's. What's the name of this disease? He isn't even familiar and a bunch of people from his apartment complex have tested positive. They hook him up to a monitor and put the pulse-ox on him and you hear "Oh ****" this guy needs oxygen too. They scramble to get a tank.

I am finally able to register my patient. They start splitting even more rooms and find a bed for her and place her in the hallway. She doesn't have a monitor so they can't monitor if the oxygen she is on becomes inadequate to keep her alive. Who knows if anyone will notice if she starts spiraling anyways? I drop her off and honestly don't know if she'll die within a few hours. That’s not a feeling I used to have. I now have that feeling with every patient I drop off. I use her phone to call her son one last time to let him know what I'm seeing. Mom isn't able to report what's going on - she’s still confused. I say they found a bed for her and she's being taken care of but it's hard to say those words without feeling some guilt. This isn't the system at its best. It isn't.
 
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Took me a while to get this down... an update...................

.................................. This isn't the system at its best. It isn't.

Like a lot of soldiers have done, now and in the past, you are going to experience feelings of guilt and "what if I'd done X?".

(and you really are medical soldiers now, all of you)

If you don't deal with it you will possibly get to PTSD levels.

I think counselling resources will be thin on the ground where you are at the moment, but keep in mind that your continued health is as important to others as it is to you, so maintain an awareness of your mental condition, as well as your physical one.

Can't do much other than wish you all the best.

Cheers
Jim
 
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Thanks, yes. In school to become a psychologist so I know the drill. Wanted to really write it out to process it. Being able to write here and connect with other providers certainly is one of my ways to "check in."

I also wanted to share the emotions part to validate that feelings get involved in this. I don't feel overwhelmed and do not feel like I do not have an adequate support system. (I've also shared this story with friends and family.) I'm the psychologist type, not one to bottle it up! 😀
 
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Australian based surgeon.

I had this in the original thread but better left here.

Cut and pasted from a medical FB group. Not my ENT colleague but useful information.

FROM AN ENT COLLEAGUE OF MINE FOLLOWING AN ON LINE MEETING:-

Interesting points shared in a group from a Zoom session with Dr. WenHong Zhang, the chair of the Society of Infectious Diseases of China Medical Association. There were about 7000 attendees, mostly United States listeners, including Stanford Health Care, Santa Clara County hospitals, and New York City hospitals. Here are some notes.

-Predicted number of cases in Shanghai with exponential growth was calculated to be nearly one million by March 1, but social distancing avoided this.

-Cases went down to zero or near zero by late-Feb, and there is now a small second wave from imported cases.

-Key to mitigating spread in Shanghai was doing diagnostic COVID test on every suspected case.

-All patients with positve COVID PCR were admitted to a designated COVID hospital regardless of their level of illness.

-Coinfection was very common with other respiratory bacteria and common cold viruses, and >50% patients were positive for a co-infection with a respiratory organism.

-False negative rate of COVID PCR even with two serial swabs was 10-30%! Next Generation Sequencing for COVID was used as the gold standard.

-RSV, Mycoplasma and Parainfluenza virus also caused similar bilateral CT findings to COVID. Molecular diagnostics was needed, and even two negative PCRs, for suspected cases on CT - they sent Next Gen Sequencing, a PCR to National Lab, a 3rd local PCR, and local PCR in another swab location (e.g. anal) (e.g. sent all 4) before they would r/o COVID.

-Mean incubation was 6.4 days, and patients were quarantined mean 5.5 days from symptom onset, with this approach the "curve" was 1 month in duration.

-Hydroxychloroquine is in a multicentre RCT in China and will be published "very soon".

-LDH and D-Dimer was associated with development of ARDS.

-He felt there is a narrow window between positive CT findings and deterioration to ARDS, where corticosteroids have been helpful and further studies are required to investigate this.

-Approxiatemately 5% of patients will need ICU level care, and mortality depends on availability of ICU.

-How to protect medical personnel - China protocol:

1) Standardized process in terms of patient care areas and flow.

2) PPE - double-layer gloves, double-layer shoe covers, isolation gown, masks, googles, etc. "The most important is to cover the head"

3) Positive pressure masks - for aerosol generating procedures.

Q&A:

-Time window until infection and test positive? 3d by PCR, and 7d by Serological.

-Who did you test? They abandoned risk factor criteria quickly and just tested anyone with symptoms.

-What is the best test? PCR is better than Antibody test for sensitivity. But the Antibody test is helpful, as PCR can have false negative by week 3. Antibody test is helpful to see the overall population prevalence in terms of patients with mild or no symptoms.

-Does viral RNA degradation of samples happen? Tests are done within 4 hours in China, or frozen at -20C otherwise there is increased false negative.

-What is risk for pregnant women? These cases were mild, and no severe/intubated cases were seen so far in Shanghai (no Wuhan data presented).

-What is the underlying medical conditions that are high risk? Heart disease do the worst - the virus causes myocarditis as well.

-What percentage of patients have antibodies? Every recovered patient tested have found to have antibodies on testing but it is unclear if these are actually protective.

-What is the dosge for hydroxychloroquine? 400mg bid x1d, 400mg po qd. They did not treat with azithromycin due to hepatotoxicity observed.

-What is the risk to health care workers? There were none of his colleagues who went to Wuhan to help that became infected with COVID, and this is attributed to PPE.

-What is the outcome of COVID survivors? Lung fibrosis is definitely less than SARS and most patients had a good long-term outcome.
 
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When I read this, it reminded me of the stories I've seen about war. We are in World War III, but we have a common enemy. To treat this as anything less is delusional.

About two weeks ago already my Chief was saying, "These are combat conditions." It took me a few days to internalize that but Thursday was certainly wartime medicine.

1. What happens right now to someone who trips on a curb or on a step, breaks an ankle or an arm, and shows up to the NY Presbyterian ER? Same question re. patients presenting with excruciating pain for a condition like a badly-herniated disc that would normally constitute an urgent elective discectomy or treatment for a kidney stone, or something similar?

If you called 9-1-1 you'd probably wait a few hours for someone to pick you up. Figure out how to get into a car and get yourself to ER.

There are still floors and doctors who do the other procedures. We dropped off a man with a GI condition and they did surgery on him.

They are starting to designate some hospitals as COVID-19 hospitals (meaning they won't take anything else) and that splitting makes just a bit more sense to me in terms of general infection control (caveat for asymptomatic transmission - so not perfect) and for being able to concentrate resources.

2. I believe patients are fully sedated start to finish.

3. There must be catheters and nursing assistants who are tending to patients. I haven't thought about this.

4. I don't know. Most patients with covid I've had have clear lungs which wouldn't really be treated by albuterol. It presents more like pneumonia on CT scan if I'm not mistaken. A more experiences medical professional can weigh in more.
 
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This caught my attention:

"Coinfection was very common with other respiratory bacteria and common cold viruses, and >50% patients were positive for a co-infection with a respiratory organism."

When discussions around those in high risk categories has happened, it's usually talking about people with chronic illness. But is this now a possible indicator that if you are an otherwise healthy person (no chronic illness) that simply having a cold, or worse seasonal flu, can put you into a high risk category?

Thanks, Al

Secondary bacterial pneumonia is actually quite common after viral pneumonia from my understanding, and it is not unique for COVID. For example, bacterial pneumonia by organisms such as staph aureus or strep pneumonia is common after the flu.
 
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Thank you. Your efforts to keep us updated and apprised of the situation is really appreciated, especially when this is how you're spending your downtime, not to mention what you're all going through (and risking) for the sake of the rest of us.

Four questions for whenever you have the time to answer:

1. What happens right now to someone who trips on a curb or on a step, breaks an ankle or an arm, and shows up to the NY Presbyterian ER? Same question re. patients presenting with excruciating pain for a condition like a badly-herniated disc that would normally constitute an urgent elective discectomy or treatment for a kidney stone, or something similar?

With the USN Comfort coming to NYC, hopefully much of that will be re-routed there. Amazingly, people have suddenly begun to re-assess just what constitutes a pain score of "10/10" and are coming to the ER less frequently. Equally amazingly, the drive for self-preservation has also led to LTCFs and nursing homes to send patients to the ER for routine staple removal(!) and "fevers" of 99.1F. These facility heads have by now hopefully been notified they have unnecessarily created new disease vectors in their facilities. Maybe they will get the message now.

Otherwise, it comes down to the patient and the provider. If the provider thinks it's serious enough, and the patient agrees, you will be treated and released/admitted.

2. When you're put on a ventilator, are you always heavily sedated or put to sleep to keep you still and spared the discomfort involved, or do people who have no choice but to be ventilated sometimes have to just lie there immobilized and in that kind of discomfort -- albeit less discomfort than suffocating slowly -- for days, until the ventilator is no longer needed?

Sedation is preferred, always. Unfortunately, many sedatives depress not only the respiratory drive (not a huge concern on a vent, but needs to be considered for purposes of possible extubation), but also blood pressure. As such, it can be a bit of a balancing act, complicated further buy tolerance levels (drug use/abuse, alcohol consumption), as well as each individual's 'preference' (what seemingly works better for some doesn't for others, all things being equal), and likely fluid restrictions for purposes of BP resuscitation due to the fluid overload in the lungs.

On the floors outside of an ER/ICU setting, many of the RNs aren't trained for handling sedation (or vents) and it gets complicated. I've heard of multiple patients extubating themselves due to lack of sedation. I've had some patients (rare) comfortable and happy to be awake, but most aren't. The former are usually on "sedation vacations", but I still will often restrain their upper extremities. I'm also lately, where possible, advocating for the use of larger ET tubes (less resistance in the circuit, slightly better perceived breathing for patients who wake up).

3. When patients are ventilated for days, how is waste elimination handled? Do they catheterize everybody on a ventilator, or what?

Any ICU patient gets a Foley, yes. It's important for measuring output (good indicator of organ perfusion in cases of ARDS/sepsis), and they can also monitor temperature in real time. The back end is handled by us, but you can use rectal tubes if the patient is experiencing frank diarrhea secondary to an infection like c.difficile.

4. Should someone who begins to experience dyspnea use an albuterol inhaler to try to resolve it at home first, or not, because of the possible detrimental effect of corticosteroids on the immune system? I was thinking that if I were in that situation, I might use the inhaler in conjunction with the disposable O2 cans that you see on NHL benches (because I happen to have a case of them for hockey).

Thanks again, in advance.

We are using MDI pumps instead of nebulizers for obvious reasons, and I have read conflicting recommendations about steroids. Some say no, while others say yes in cases of elevated interleukin-6.


This caught my attention:

"Coinfection was very common with other respiratory bacteria and common cold viruses, and >50% patients were positive for a co-infection with a respiratory organism."

When discussions around those in high risk categories has happened, it's usually talking about people with chronic illness. But is this now a possible indicator that if you are an otherwise healthy person (no chronic illness) that simply having a cold, or worse seasonal flu, can put you into a high risk category?

Thanks, Al

I mentioned this in previous posts, here and/or elsewhere. Before the wave really hit, people could have been experiencing seasonal allergies, or maybe had some mild congestion, a sore throat, or even an ear ache, and that could possibly be enough of a heightened immune response for some people where the addition of C19 turns into an overwhelming illness. Same holds true for the flu shot which was continuing to be recommended early on in this.

An old doctor axiom is 'when you hear hoofbeats think horses, not zebras.' So, what to do here? I think a bit of both, but I would get the cowboys ready.

Right now, one of the hoofbeats we are hearing is the seemingly common and often well-controlled condition of hypertension being in the top 2(?) of comorbidities. Since the virus inserts itself on the same protein associated with the primary mechanism of two of the most widely prescribed medications to control hypertension, that's reason to believe you've heard another hoofbeat. Add in a third one with the mechanism for the cytokine storm seen with ARDS responses being associated with that same protein, and I am going to go ahead and say it's a horse. But right now, people with more letters at the ends of their names than me are controlling the narrative and saying "we need more data, keep taking your medications as prescribed by your doctor." In other words, they still think there's a good chance that what they are hearing is a zebra. Ironic, and tragic.
Edited:
 
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At this time, multiple cardiovascular societies have recommended patients to not discontinue their ACEi or ARB as insufficient evidence currently exists that risk of COViD 19 infection is increased with concomitant use of these medications. There are studies that have shown that ACEi may reduce risk/mortality from viral pneumonia and thus may be beneficial to those at risk of COVID infection. Remember patients on these medications are on them to treat hypertension and to try switch to another antihypertensive medication(s) takes time to titrate properly which draws time away from an already overworked medical staff in light of the inconclusive evidence. Trying to switch these antihypertensive medications on a patient in the midst of battling a COVID infection may cause their BP to spike to deleterious levels.
 
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At this time, multiple cardiovascular societies have recommended patients to not discontinue their ACEi or ARB as insufficient evidence currently exists that risk of COViD 19 infection is increased with concomitant use of these medications. There are studies that have shown that ACEi may reduce risk/mortality from viral pneumonia and thus may be beneficial to those at risk of COVID infection. Remember patients on these medications are on them to treat hypertension and to try switch to another antihypertensive medication(s) takes time to titrate properly which draws time away from an already overworked medical staff in light of the inconclusive evidence. Trying to switch these antihypertensive medications on a patient in the midst of battling a COVID infection may cause their BP to spike to deleterious levels.

And that's terrific for those societies. The potential benefit of an ACEi in helping someone with a viral PNA is wonderful, too, but we are not seeing that right now with C19. There is sufficient evidence at this time to support a pause on use of these medications via titration or switching to a different class, neither of which is overly difficult considering many of these specialist's practices are not overworked as they are currently closed or are only doing telehealth (which is awesome and a long time coming). The patients who are on these medications and infected are, in fact, becoming hypotensive, likely due to the body's inability to rally RAAS due to a completely dysfunctional ACE/ARB component coupled with.....an overwhelming viral PNA leading to an ARDS state.

Again, I realize there are a lot of people with higher degrees/licensure recommending the status quo. What they aren't saying is that there isn't a connection. Know why? Because there are a whole lot more people with lesser degrees on the frontlines offering up so much first hand, anecdotal reports, that it's turning into a data set. I cannot ethically ignore that, and have in turn asked my father to contact his doctor about a switch/titration.

As always, consult with your doctor before making changes in your prescribed treatment. 😗
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We are in a war where we need to use different methods. I am glad there are government efforts to streamline very slow inefficient processes to get results. The world cases are going to increase rapidly for at least another two weeks. Hopefully it will slow then. We need a breakthru now in treatment where it will be most helpful.

Truer words have never been said. This is why I responded above the way I did. The time for measured, non-committal, canned responses will come again, but now is not the time for them. Treatment modalities, disease proliferation mitigation, identification of the 'why' in vulnerable groups are key right now, along with antigen testing, with a vaccine bringing up the rear (as it should be). If we are seeing trends in any of the above, we have an ethical obligation to pursue them, not to wait on scientific consensus 🤮to come around to what people are seeing before trying to literally save lives.

This is turning into a thread drift, and I am sorry for the part I have played in it. I shared what I am seeing as I treat these patients in the hopes that it may 1) help another provider and 1a) save a patient or prevent someone from becoming one. @Rasputin response does nothing to do either as it is recommending that we ignore the trends and keep the status quo, which right now, is not the status quo; it's war. So we need a wartime consigliere. You're out, Tom
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