The primary chemical difference is an amide vs. ester linkage in the molecules.
Nylon is a specific type of polyamide and is softer than polyester but also stronger (tensile strength).
Polyester is faster drying, easier to dye and has better abrasion resistance, which in a watch strap makes it less, not more, likely to pill.
Nylon is more expensive to produce and, depending on the application, may require additional treatment for abrasion resistance.
I don’t know that one is “better” than the other in a watch strap, quality is in the eye of the beholder for many consumer goods.
Click to expand...